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+# KétaPK - Pharmacokinetic Simulation for Anesthesia & Intensive Care
+
+**KétaPK** is a modern, cross-platform pharmacokinetic (PK) and pharmacodynamic (PD) modeling application for **Esketamine** and **Racemic Ketamine**. It allows anesthesiologists, intensive care physicians, and clinical researchers to simulate, visualize, and predict plasma drug concentrations ($C_p$) over a 300-minute timeline using multi-exponential models.
+
+---
+
+## 1. Overview & Purpose
+
+* **Original Creator:** Dr. Georges Mion (Anesthesiologist-Intensivist)
+* **Purpose:** To provide clinical specialists with an instantaneous, offline, and reliable decision-support and simulation tool for IV bolus doses and continuous infusions.
+* **Core PK Models Integrated:**
+* **Domino et al. (1982)** — Three-compartment model ($2.0\text{ mg/kg}$ reference)
+* **Clements et al. (1981)** — Two-compartment model ($0.25\text{ mg/kg}$ reference)
+* **Kamp et al. (2020)** — Meta-analytic multi-compartment model ($0.5\text{ mg/kg}$ reference)
+
+---
+
+## 2. Project Origin & AI Generation Transparency
+
+### The Legacy Application
+
+The initial version of **KétaPK** was hand-crafted as a Microsoft Excel workbook (`.xlsm`) using complex VBA (Visual Basic for Applications) macros, custom chart event listeners, and dynamic range colorizations.
+
+### Modernization via AI Collaboration
+
+To make the tool responsive, cross-platform, and independent of Microsoft Office, the application was re-engineered into a modern web and desktop software stack.
+
+* **AI Collaboration Model:** Google Gemini
+* **AI Model Version:** Gemini 2.6 Thinking
+* **Generation Mode:** Context-aware multi-turn prompt engineering & source-code decompilation
+* **Generation Parameters:** Standard System Instructions, Default Temperature (~0.7), Strict Module Separation (Decoupled Math Engine / Responsive UI / i18n Dictionary)
+
+---
+
+## 3. Legacy Excel Implementation
+
+The original spreadsheet relied on embedded OLE streams, sheet-level event macros (`Worksheet_SelectionChange`), and manual range formulas to calculate 61 time points (0 to 300 minutes in 5-minute increments).
+
+> **Learn more about the original implementation:**
+> [View Original Excel/VBA Application Documentation & Walkthrough](https://georgesmion.com/ketapk-simuler-les-concentrations-plasmatiques-de-ketamine/)
+
+---
+
+## 4. Running with Docker
+
+You can run **KétaPK** in an isolated container using Docker or Docker Compose.
+
+### Option A: Using Docker CLI
+
+```bash
+# Build the Docker image using the non-root secure Dockerfile
+docker build -t ketapk-web .
+```
+
+```bash
+# Run the container mapping port 3000 on your host machine
+docker run -d -p 3000:3000 --name ketapk-app ketapk-web
+```
+
+```bash
+# Access the application in your browser at http://localhost:3000
+```
+
+### Option B: Using Docker Compose (Recommended)
+
+```bash
+# Build and start the containerized application in detached mode
+docker compose up -d --build
+```
+
+```bash
+# Stop and remove the running container environment
+docker compose down
+```
+
+---
+
+## 5. Compiling Desktop Apps with Tauri (Windows, macOS, Linux)
+
+**KétaPK** uses **Tauri v2** to generate ultra-lightweight ($\sim 12\text{ MB}$), native desktop executables (`.exe`, `.dmg`, `.AppImage`) that operate 100% offline without requiring Node.js or Docker on the target medical machine.
+
+### Prerequisites
+
+* **Node.js** (v20 or higher)
+* **Rust & Cargo** (installed via [rustup.rs](https://rustup.rs/))
+* *Windows:* C++ Build Tools for Visual Studio
+* *macOS:* Xcode Command Line Tools (`xcode-select --install`)
+
+### Step-by-Step Build Process
+
+```bash
+# 1. Install project dependencies
+npm install
+```
+
+```bash
+# 2. Compile the static Tailwind CSS bundle
+npm run build:css
+```
+
+```bash
+# 3. Launch the application in desktop development mode (with Hot Reload)
+npx tauri dev
+```
+
+```bash
+# 4. Compile the production installer for your current Operating System
+npx tauri build
+```
+
+---
+
+## Output Installation Binaries
+
+After running `npx tauri build`, your standalone installer will be available at:
+
+* **Windows:** `src-tauri/target/release/bundle/nsis/KetaPK_1.0.0_x64-setup.exe`
+* **macOS:** `src-tauri/target/release/bundle/dmg/KetaPK_1.0.0_x64.dmg`
+* **Linux:** `src-tauri/target/release/bundle/appimage/KetaPK_1.0.0_amd64.AppImage`
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