diff --git a/.gitignore b/.gitignore
index 4bde02f..9c80401 100644
--- a/.gitignore
+++ b/.gitignore
@@ -1,7 +1,8 @@
 # Origin project
-*.xlsm
+*.xls*
 *.zip
-code_vba*.txt
+*.txt
+*.png
 
 # Node files
 node_modules/
diff --git a/frontend/js/chartManager.js b/frontend/js/chartManager.js
index f415c49..2b2e224 100644
--- a/frontend/js/chartManager.js
+++ b/frontend/js/chartManager.js
@@ -1,21 +1,11 @@
 import { CLINICAL_THRESHOLDS } from './pkCore.js';
 import { t } from './i18n.js';
 
-// Le texte des zones cliniques (zone.textHex) est calibré pour un fond sombre.
-// Sur le thème clair, il faut un texte foncé pour rester lisible sur le même fond pastel.
-const LIGHT_THEME_ZONE_TEXT = {
-  inactive: '#854d0e',
-  anti_hyperalgesic: '#3f6212',
-  analgesia: '#92400e',
-  psychedelic: '#9d174d',
-  emergence: '#075985',
-  narcosis: '#1e3a8a',
-  excessive: '#7f1d1d'
-};
-
+// Les couleurs de zone sont volontairement fixes (indépendantes du thème d'interface) :
+// elles reproduisent le dégradé de référence de l'outil KetaPK original. Seul le texte
+// (zone.textHex) est choisi pour rester lisible sur cette couleur de fond opaque.
 export function updateChartAnnotations(chart, mode, currentYMax) {
   const thresholds = CLINICAL_THRESHOLDS[mode];
-  const theme = document.documentElement.getAttribute('data-theme') || 'dark';
   const annotations = {};
 
   thresholds.zones.forEach((zone, index) => {
@@ -24,6 +14,7 @@ export function updateChartAnnotations(chart, mode, currentYMax) {
 
       annotations[`zone_${index}`] = {
         type: 'box',
+        drawTime: 'beforeDraw',
         yMin: zone.min,
         yMax: Math.min(zoneMax, currentYMax),
         backgroundColor: zone.color,
@@ -31,7 +22,7 @@ export function updateChartAnnotations(chart, mode, currentYMax) {
         label: {
           display: true,
           content: t(`zones.${zone.zoneKey}`),
-          color: theme === 'light' ? (LIGHT_THEME_ZONE_TEXT[zone.zoneKey] || '#1e293b') : zone.textHex,
+          color: zone.textHex,
           font: { size: 11, weight: 'bold' },
           position: 'center'
         }
diff --git a/frontend/js/pkCore.js b/frontend/js/pkCore.js
index dcd46d2..81d3f64 100644
--- a/frontend/js/pkCore.js
+++ b/frontend/js/pkCore.js
@@ -8,7 +8,7 @@
 /**
  * Version unique de l'application (Centralisée)
  */
-export const APP_VERSION = '0.18.0';
+export const APP_VERSION = '0.19.0';
 
 export const MODES = {
   ESKETAMINE: 'ESKETAMINE',
@@ -49,26 +49,26 @@ export const CLINICAL_THRESHOLDS = {
     maxScale: 500,
     defaultConcentration: 5,
     zones: [
-      { zoneKey: "inactive", min: 0, max: 10, color: "rgba(249, 252, 126, 0.25)", textHex: "#fef9c3" },
-      { zoneKey: "anti_hyperalgesic", min: 10, max: 50, color: "rgba(218, 247, 166, 0.25)", textHex: "#d9f99d" },
-      { zoneKey: "analgesia", min: 50, max: 150, color: "rgba(255, 195, 0, 0.25)", textHex: "#fef08a" },
-      { zoneKey: "psychedelic", min: 150, max: 350, color: "rgba(242, 160, 223, 0.25)", textHex: "#fbcfe8" },
-      { zoneKey: "emergence", min: 350, max: 500, color: "rgba(89, 196, 240, 0.25)", textHex: "#bae6fd" },
-      { zoneKey: "narcosis", min: 500, max: 1000, color: "rgba(43, 122, 244, 0.25)", textHex: "#ffffff" },
-      { zoneKey: "excessive", min: 1000, max: Infinity, color: "rgba(255, 87, 51, 0.25)", textHex: "#fecaca" }
+      { zoneKey: "inactive", min: 0, max: 10, color: "#eaf7d8", textHex: "#4d5a1e" },
+      { zoneKey: "anti_hyperalgesic", min: 10, max: 50, color: "#ddf78a", textHex: "#355e1a" },
+      { zoneKey: "analgesia", min: 50, max: 150, color: "#ffcc33", textHex: "#7a4a00" },
+      { zoneKey: "psychedelic", min: 150, max: 350, color: "#f562f0", textHex: "#6b0f61" },
+      { zoneKey: "emergence", min: 350, max: 500, color: "#4fd3f7", textHex: "#013a4d" },
+      { zoneKey: "narcosis", min: 500, max: 1000, color: "#0ea5f0", textHex: "#ffffff" },
+      { zoneKey: "excessive", min: 1000, max: Infinity, color: "#ff4d4d", textHex: "#ffffff" }
     ]
   },
   [MODES.RACEMIQUE]: {
     maxScale: 1000,
     defaultConcentration: 10,
     zones: [
-      { zoneKey: "inactive", min: 0, max: 20, color: "rgba(249, 252, 126, 0.25)", textHex: "#fef9c3" },
-      { zoneKey: "anti_hyperalgesic", min: 20, max: 100, color: "rgba(218, 247, 166, 0.25)", textHex: "#d9f99d" },
-      { zoneKey: "analgesia", min: 100, max: 300, color: "rgba(255, 195, 0, 0.25)", textHex: "#fef08a" },
-      { zoneKey: "psychedelic", min: 300, max: 700, color: "rgba(242, 160, 223, 0.25)", textHex: "#fbcfe8" },
-      { zoneKey: "emergence", min: 700, max: 1000, color: "rgba(89, 196, 240, 0.25)", textHex: "#bae6fd" },
-      { zoneKey: "narcosis", min: 1000, max: 2000, color: "rgba(43, 122, 244, 0.25)", textHex: "#ffffff" },
-      { zoneKey: "excessive", min: 2000, max: Infinity, color: "rgba(255, 87, 51, 0.25)", textHex: "#fecaca" }
+      { zoneKey: "inactive", min: 0, max: 20, color: "#eaf7d8", textHex: "#4d5a1e" },
+      { zoneKey: "anti_hyperalgesic", min: 20, max: 100, color: "#ddf78a", textHex: "#355e1a" },
+      { zoneKey: "analgesia", min: 100, max: 300, color: "#ffcc33", textHex: "#7a4a00" },
+      { zoneKey: "psychedelic", min: 300, max: 700, color: "#f562f0", textHex: "#6b0f61" },
+      { zoneKey: "emergence", min: 700, max: 1000, color: "#4fd3f7", textHex: "#013a4d" },
+      { zoneKey: "narcosis", min: 1000, max: 2000, color: "#0ea5f0", textHex: "#ffffff" },
+      { zoneKey: "excessive", min: 2000, max: Infinity, color: "#ff4d4d", textHex: "#ffffff" }
     ]
   }
 };
@@ -191,7 +191,8 @@ export function generateSimulationData({ model, weightKg, timelineInputs, infusi
     if (!nextEvent) return;
 
     const deltaT = nextEvent.time - event.time;
-    const Rn = infusionRateToMgKgPerMin(event.infusionRate, infusionUnit, weightKg) / refDose;
+    // Excel applique le débit déclaré à la fin de l'intervalle (colonne d'arrivée), pas celui du départ
+    const Rn = infusionRateToMgKgPerMin(nextEvent.infusionRate, infusionUnit, weightKg) / refDose;
 
     const Falpha = Math.exp(-alpha * deltaT);
     const Fbeta = Math.exp(-beta * deltaT);
diff --git a/pyproject.toml b/pyproject.toml
index ecb91ab..f0e9d56 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -1,6 +1,6 @@
 [project]
 name = "ketapk"
-version = "0.1.0"
+version = "0.19.0"
 description = "Add your description here"
 readme = "README.md"
 requires-python = ">=3.14"
diff --git a/src-tauri/Cargo.lock b/src-tauri/Cargo.lock
index 298a4ee..226eb4f 100644
--- a/src-tauri/Cargo.lock
+++ b/src-tauri/Cargo.lock
@@ -1616,7 +1616,7 @@ dependencies = [
 
 [[package]]
 name = "ketapk"
-version = "0.18.0"
+version = "0.19.0"
 dependencies = [
  "log",
  "serde",
diff --git a/src-tauri/Cargo.toml b/src-tauri/Cargo.toml
index dce8cef..1069859 100644
--- a/src-tauri/Cargo.toml
+++ b/src-tauri/Cargo.toml
@@ -1,6 +1,6 @@
 [package]
 name = "ketapk"
-version = "0.18.0"
+version = "0.19.0"
 description = "KétaPK"
 authors = ["Pr. Georges MION", "Gauvain BOICHÉ"]
 license = "Proprietary"
diff --git a/src-tauri/tauri.conf.json b/src-tauri/tauri.conf.json
index ac60f02..f5dd3b5 100644
--- a/src-tauri/tauri.conf.json
+++ b/src-tauri/tauri.conf.json
@@ -1,7 +1,7 @@
 {
   "$schema": "https://schema.tauri.app/config/2",
   "productName": "ketapk",
-  "version": "0.18.0",
+  "version": "0.19.0",
   "identifier": "com.ketapk.desktop",
   "build": {
     "beforeDevCommand": "",