mirror of
https://github.com/gauvainboiche/ketapk.git
synced 2026-09-02 11:13:11 +02:00
gauvainboiche
318 lines
17 KiB
HTML
318 lines
17 KiB
HTML
<!DOCTYPE html>
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<html lang="fr" data-theme="dark" class="min-h-screen bg-[var(--kt-bg)] text-[var(--kt-text-1)]">
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<head>
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<meta charset="UTF-8">
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<meta name="viewport" content="width=device-width, initial-scale=1.0">
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<title>KétaPK - Simulation Pharmacocinétique</title>
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<!-- CSS Tailwind compilé -->
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<link rel="stylesheet" href="css/tailwind.css">
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<!-- CSS Personnalisé -->
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<link rel="stylesheet" href="css/styles.css">
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<!-- Librairies JS Statiques -->
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<script src="vendor/chart.umd.min.js"></script>
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<script src="vendor/chartjs-plugin-annotation.min.js"></script>
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</head>
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<body class="min-h-screen flex flex-col font-sans antialiased selection:bg-amber-500 selection:text-slate-950">
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<!-- NAVBAR -->
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<header class="bg-[var(--kt-surface-1)] backdrop-blur border-b border-[var(--kt-border)] sticky top-0 z-40 shadow-lg">
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<div class="max-w-[1800px] w-full mx-auto px-6 py-3 flex flex-wrap items-center justify-between gap-4">
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<!-- Logo -->
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<div class="flex items-center gap-3">
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<div
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class="bg-gradient-to-r from-amber-500 to-amber-600 text-slate-950 font-black px-3.5 py-1 rounded-xl text-xl tracking-wider shadow-md shadow-amber-500/20">
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KétaPK
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</div>
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<div class="flex flex-col">
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<span data-i18n="app.title" class="text-sm font-bold text-[var(--kt-text-1)] leading-none">Pharmaco Kinetics</span>
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<span data-i18n="app.version" class="text-[10px] text-[var(--kt-text-3)] font-mono">v1.00 • Dr Georges Mion</span>
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</div>
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</div>
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<!-- Mode Selector -->
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<div class="flex items-center bg-[var(--kt-surface-3)] p-1 rounded-xl border border-[var(--kt-border)] shadow-inner">
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<button id="btnEsk" type="button" data-i18n="nav.mode_esk"
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class="px-4 py-1.5 rounded-lg text-xs font-bold transition-all bg-amber-500 text-slate-950 shadow-md shadow-amber-500/30">
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ESKETAMINE
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</button>
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<button id="btnRac" type="button" data-i18n="nav.mode_rac"
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class="px-4 py-1.5 rounded-lg text-xs font-bold transition-all text-[var(--kt-text-3)] hover:text-[var(--kt-text-1)]">
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RACÉMIQUE
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</button>
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</div>
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<!-- Actions & Language -->
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<div class="flex items-center gap-2">
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<div class="flex items-center gap-1 bg-[var(--kt-surface-3)] border border-[var(--kt-border)] rounded-xl px-2 py-1">
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<span class="text-xs">🎨</span>
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<select id="selectTheme" class="bg-transparent text-xs font-bold text-[var(--kt-text-2)] outline-none cursor-pointer">
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<option value="dark" class="bg-[var(--kt-option-bg)]" data-i18n="theme.dark">Sombre</option>
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<option value="light" class="bg-[var(--kt-option-bg)]" data-i18n="theme.light">Clair</option>
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<option value="monokai" class="bg-[var(--kt-option-bg)]" data-i18n="theme.monokai">Monokai</option>
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</select>
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</div>
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<div class="flex items-center gap-1 bg-[var(--kt-surface-3)] border border-[var(--kt-border)] rounded-xl px-2 py-1">
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<span class="text-xs">🌐</span>
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<select id="selectLang" class="bg-transparent text-xs font-bold text-[var(--kt-text-2)] outline-none cursor-pointer">
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<option value="fr" class="bg-[var(--kt-option-bg)]">FR</option>
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<option value="en" class="bg-[var(--kt-option-bg)]">EN</option>
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<option value="cn" class="bg-[var(--kt-option-bg)]">CN</option>
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</select>
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</div>
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<button id="btnOpenCalc" type="button"
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class="bg-[var(--kt-btn-bg)] hover:bg-[var(--kt-btn-bg-hover)] text-[var(--kt-text-1)] border border-[var(--kt-border-soft)] px-3 py-1.5 rounded-lg text-xs font-medium transition flex items-center gap-1.5 shadow-sm">
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<span>🧮</span>
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<span data-i18n="nav.calculator" class="hidden sm:inline">Calculateur</span>
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</button>
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<button id="btnExportCSVNav" type="button"
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class="bg-emerald-600/90 hover:bg-emerald-500 text-white border border-emerald-500/50 px-3 py-1.5 rounded-lg text-xs font-semibold transition flex items-center gap-1.5 shadow-md shadow-emerald-600/20">
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<span>📊</span>
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<span data-i18n="nav.export_csv" class="hidden sm:inline">Exporter CSV</span>
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</button>
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<button id="btnRaz" type="button"
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class="bg-rose-500/10 hover:bg-rose-500/20 text-rose-400 border border-rose-500/30 px-3 py-1.5 rounded-lg text-xs font-medium transition flex items-center gap-1.5">
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<span>🔄</span>
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<span data-i18n="nav.raz" class="hidden sm:inline">RAZ</span>
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</button>
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</div>
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</div>
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</header>
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<!-- MAIN -->
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<main class="flex-1 max-w-[1800px] w-full mx-auto p-6 grid grid-cols-1 lg:grid-cols-12 xl:grid-cols-12 gap-6">
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<!-- SIDEBAR -->
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<aside class="lg:col-span-3 xl:col-span-2 space-y-5">
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<!-- Panneau Patient -->
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<div class="bg-[var(--kt-surface-2)] p-4 rounded-xl border border-[var(--kt-border)] shadow-md mb-6">
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<div class="grid grid-cols-1 gap-4 items-center">
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<!-- Nom du Patient -->
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<div>
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<label data-i18n="patient.name_label" class="block text-xs text-[var(--kt-text-3)] mb-1 font-medium">Nom du patient</label>
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<input type="text" id="patientName" data-i18n-placeholder="patient.name_placeholder" placeholder="ex: DUPONT Jean"
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class="w-full bg-[var(--kt-bg)] border border-[var(--kt-border)] rounded-lg px-3 py-2 text-[var(--kt-text-1)] font-bold focus:border-cyan-500 focus:outline-none">
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</div>
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<!-- Poids + Avertissement -->
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<div>
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<label data-i18n="patient.weight_label" class="block text-xs text-[var(--kt-text-3)] mb-1 font-medium">Poids du patient (kg)</label>
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<input type="number" id="patientWeight" value="70" min="10" max="250" step="any"
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class="w-full bg-[var(--kt-bg)] border border-[var(--kt-border)] rounded-lg px-3 py-2 text-[var(--kt-text-1)] font-bold focus:border-cyan-500 focus:outline-none">
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<div id="weightWarning" class="hidden text-amber-400 text-xs mt-1.5 flex items-center gap-1 font-medium"
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data-i18n="patient.weight_warning">
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⚠️ Modèles pharmacocinétiques non garantis hors de la plage 30 - 120 kg.
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</div>
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</div>
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<!-- Choix Unité Perfusion -->
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<div>
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<label data-i18n="patient.infusion_unit_label" class="block text-xs text-[var(--kt-text-3)] mb-1 font-medium">Unité de perfusion continue</label>
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<select id="infusionUnitSelect"
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class="w-full bg-[var(--kt-bg)] border border-[var(--kt-border)] rounded-lg px-3 py-2 text-[var(--kt-text-1)] font-semibold focus:border-cyan-500 focus:outline-none">
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<option value="mg_kg_h" data-i18n="units.mg_kg_h">mg / kg / h</option>
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<option value="mcg_kg_min" data-i18n="units.mcg_kg_min">µg / kg / min</option>
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<option value="mg_h" data-i18n="units.mg_h">mg / h (dose fixe)</option>
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</select>
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</div>
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<!-- Résolution temporelle de la timeline -->
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<div>
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<label data-i18n="patient.timeline_resolution_label" class="block text-xs text-[var(--kt-text-3)] mb-1 font-medium">Résolution de la timeline</label>
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<div class="grid grid-cols-2 gap-2">
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<div>
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<label for="timerInput" data-i18n="patient.timer_label" class="block text-[10px] text-[var(--kt-text-3)] mb-0.5">Timer (min)</label>
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<input type="number" id="timerInput" value="5" min="1" step="1" inputmode="numeric"
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class="w-full bg-[var(--kt-bg)] border border-[var(--kt-border)] rounded-lg px-3 py-2 text-[var(--kt-text-1)] font-bold focus:border-cyan-500 focus:outline-none">
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</div>
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<div>
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<label for="timespanInput" data-i18n="patient.timespan_label" class="block text-[10px] text-[var(--kt-text-3)] mb-0.5">Timespan (valeurs)</label>
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<input type="number" id="timespanInput" value="60" min="1" max="500" step="1" inputmode="numeric"
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class="w-full bg-[var(--kt-bg)] border border-[var(--kt-border)] rounded-lg px-3 py-2 text-[var(--kt-text-1)] font-bold focus:border-cyan-500 focus:outline-none">
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</div>
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</div>
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<div id="totalTimespanDisplay" class="text-[10px] text-[var(--kt-text-3)] mt-1.5 font-mono"></div>
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</div>
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</div>
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</div>
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<!-- Bouton d'exportation CSV Lateral -->
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<div class="flex justify-end gap-3 mb-4">
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<button id="btnExportCSV" data-i18n="buttons.export_csv"
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class="bg-[var(--kt-btn-bg)] hover:bg-[var(--kt-btn-bg-hover)] text-[var(--kt-text-1)] text-xs font-semibold px-3 py-2 rounded-lg flex items-center gap-2 transition w-full justify-center">
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📊 Exporter valeurs CSV (ng/mL)
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</button>
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</div>
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<!-- Models Selection -->
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<div class="bg-[var(--kt-surface-2)] border border-[var(--kt-border)] rounded-2xl p-4 shadow-md backdrop-blur-sm">
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<h2 data-i18n="models.title"
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class="text-xs font-bold text-[var(--kt-text-3)] uppercase tracking-wider mb-3 border-b border-[var(--kt-border-soft)] pb-2 flex items-center gap-2">
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<span>📈</span> Modèles Pharmacocinétiques
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</h2>
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<div class="space-y-2">
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<label
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class="flex items-center justify-between p-2.5 bg-[var(--kt-surface-3)] border border-[var(--kt-border-soft)] rounded-xl cursor-pointer hover:bg-[var(--kt-btn-bg)] transition">
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<span class="text-xs font-bold text-orange-400">Domino et al. (1982)</span>
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<input type="checkbox" id="chkDomino" checked class="w-4 h-4 accent-orange-500 rounded cursor-pointer">
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</label>
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<label
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class="flex items-center justify-between p-2.5 bg-[var(--kt-surface-3)] border border-[var(--kt-border-soft)] rounded-xl cursor-pointer hover:bg-[var(--kt-btn-bg)] transition">
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<span class="text-xs font-bold text-emerald-400">Clements et al. (1981)</span>
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<input type="checkbox" id="chkClements" checked class="w-4 h-4 accent-emerald-500 rounded cursor-pointer">
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</label>
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<label
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class="flex items-center justify-between p-2.5 bg-[var(--kt-surface-3)] border border-[var(--kt-border-soft)] rounded-xl cursor-pointer hover:bg-[var(--kt-btn-bg)] transition">
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<span class="text-xs font-bold text-sky-400">Kamp et al. (2020)</span>
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<input type="checkbox" id="chkKamp" checked class="w-4 h-4 accent-sky-500 rounded cursor-pointer">
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</label>
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</div>
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</div>
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</aside>
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<!-- CONTENT -->
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<section class="lg:col-span-9 xl:col-span-10 space-y-5 flex flex-col">
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<!-- Graphique dynamique -->
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<div
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class="bg-[var(--kt-surface-2)] border border-[var(--kt-border)] rounded-2xl p-4 shadow-md backdrop-blur-sm flex flex-col h-[calc(100vh-370px)] min-h-[450px] relative">
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<div class="flex-1 w-full h-full relative">
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<canvas id="pkChart"></canvas>
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</div>
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</div>
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<!-- Timeline Grid -->
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<div class="bg-[var(--kt-surface-2)] border border-[var(--kt-border)] rounded-2xl p-4 shadow-md backdrop-blur-sm">
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<div class="flex items-center justify-between mb-3 border-b border-[var(--kt-border-soft)] pb-2">
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<h2 data-i18n="timeline.title"
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class="text-xs font-bold text-[var(--kt-text-2)] uppercase tracking-wider flex items-center gap-2">
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<span>⏱️</span> Saisie Chronologique Doses & Perfusion (0 - 300 min)
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</h2>
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<span data-i18n="timeline.scroll_hint" class="text-[10px] text-[var(--kt-text-3)] italic">Défilement horizontal 👉</span>
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</div>
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<div id="timelineGrid"
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class="flex gap-2 overflow-x-auto pb-2 scrollbar-thin scrollbar-thumb-[var(--kt-scroll-thumb)] scrollbar-track-[var(--kt-scroll-track)]">
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<!-- Injecté via app.js -->
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</div>
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</div>
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<!-- Tableau de contrôle des concentrations (0-300 min) -->
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<details class="bg-[var(--kt-surface-2)] border border-[var(--kt-border)] rounded-xl mb-6">
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<summary
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class="p-4 cursor-pointer text-[var(--kt-text-2)] font-semibold text-sm hover:text-[var(--kt-text-1)] flex justify-between items-center">
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<span data-i18n="table.summary_title">🔍 Tableau de contrôle des concentrations calculées (0 - 300 min)</span>
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<span data-i18n="table.summary_subtitle" class="text-xs text-[var(--kt-text-3)]">Cliquer pour afficher/masquer</span>
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</summary>
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<div class="p-4 border-t border-[var(--kt-border)] overflow-x-auto max-h-80">
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<table class="w-full text-xs text-left text-[var(--kt-text-2)]">
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<thead class="text-[var(--kt-text-3)] bg-[var(--kt-surface-3)] uppercase font-mono sticky top-0">
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<tr>
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<th data-i18n="table.col_time" class="px-3 py-2">Temps</th>
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<th data-i18n="table.col_bolus" class="px-3 py-2">Bolus (mg)</th>
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<th data-i18n="table.col_infusion" class="px-3 py-2">Perf. Active</th>
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<th data-i18n="table.col_domino" class="px-3 py-2 text-cyan-400">Domino (ng/mL)</th>
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<th data-i18n="table.col_clements" class="px-3 py-2 text-emerald-400">Clements (ng/mL)</th>
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<th data-i18n="table.col_kamp" class="px-3 py-2 text-purple-400">Kamp (ng/mL)</th>
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</tr>
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</thead>
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<tbody id="dataTableBody" class="divide-y divide-[var(--kt-border-soft)] font-mono">
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<!-- Généré dynamiquement en JS -->
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</tbody>
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</table>
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</div>
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</details>
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</section>
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</main>
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<!-- MODAL CALCULATOR -->
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<div id="modalCalc"
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class="fixed inset-0 bg-black/60 backdrop-blur-sm z-50 hidden flex items-center justify-center p-4 transition-opacity">
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<div class="bg-[var(--kt-surface-modal)] border border-[var(--kt-border)] rounded-2xl w-full max-w-lg p-6 space-y-6 shadow-2xl relative">
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<div class="flex justify-between items-center border-b border-[var(--kt-border)] pb-3">
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<h3 data-i18n="calculator.title" class="text-base font-bold text-amber-400 flex items-center gap-2">
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<span>🧮</span> Calculateur & Conversions de Doses
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</h3>
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<button id="btnCloseCalc" type="button"
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class="text-[var(--kt-text-3)] hover:text-[var(--kt-text-1)] font-bold text-xl leading-none transition">×</button>
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</div>
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<div class="space-y-4">
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<div class="grid grid-cols-2 gap-3 bg-[var(--kt-surface-3)] p-3 rounded-xl border border-[var(--kt-border)]">
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<div>
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<label for="calcWeight" data-i18n="calculator.patient_weight"
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class="block text-xs text-[var(--kt-text-3)] mb-1">Poids du patient</label>
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<div class="flex items-center gap-1">
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<input type="number" id="calcWeight" value="70" step="any"
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class="w-full bg-[var(--kt-surface-2)] border border-[var(--kt-border)] rounded-lg p-2 text-sm text-[var(--kt-text-1)] font-bold outline-none">
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<span class="text-xs text-[var(--kt-text-3)]">kg</span>
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</div>
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</div>
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</div>
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<div>
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<h4 data-i18n="calculator.bolus_header"
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class="text-xs font-semibold text-[var(--kt-text-3)] uppercase tracking-wider mb-2">Conversion Bolus</h4>
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<div class="grid grid-cols-2 gap-3">
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<div>
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<label for="calcMg" data-i18n="calculator.total_dose" class="block text-[10px] text-[var(--kt-text-3)] mb-1">Dose totale (mg)</label>
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<input type="number" id="calcMg" step="any" placeholder="ex: 35"
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class="w-full bg-[var(--kt-bg)] border border-[var(--kt-border)] rounded-lg p-2 text-sm text-[var(--kt-text-1)] focus:ring-1 focus:ring-amber-500 outline-none">
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</div>
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<div>
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<label for="calcMgKg" data-i18n="calculator.relative_dose"
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class="block text-[10px] text-[var(--kt-text-3)] mb-1">Dose relative (mg/kg)</label>
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<input type="number" id="calcMgKg" step="any" placeholder="ex: 0.5"
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class="w-full bg-[var(--kt-bg)] border border-[var(--kt-border)] rounded-lg p-2 text-sm text-[var(--kt-text-1)] focus:ring-1 focus:ring-amber-500 outline-none">
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</div>
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</div>
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</div>
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<div>
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<h4 data-i18n="calculator.infusion_header"
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class="text-xs font-semibold text-[var(--kt-text-3)] uppercase tracking-wider mb-2">Conversion Perfusion</h4>
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<div class="grid grid-cols-2 gap-3">
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<div>
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<label for="calcMgKgH" data-i18n="calculator.rate_mgkgh"
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class="block text-[10px] text-[var(--kt-text-3)] mb-1">Débit (mg/kg/h)</label>
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<input type="number" id="calcMgKgH" step="any" placeholder="ex: 0.3"
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class="w-full bg-[var(--kt-bg)] border border-[var(--kt-border)] rounded-lg p-2 text-sm text-[var(--kt-text-1)] focus:ring-1 focus:ring-amber-500 outline-none">
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</div>
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<div>
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<label for="calcUgKgMin" data-i18n="calculator.rate_ugkgmin"
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class="block text-[10px] text-[var(--kt-text-3)] mb-1">Débit (µg/kg/min)</label>
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<input type="number" id="calcUgKgMin" step="any" placeholder="ex: 5"
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class="w-full bg-[var(--kt-bg)] border border-[var(--kt-border)] rounded-lg p-2 text-sm text-[var(--kt-text-1)] focus:ring-1 focus:ring-amber-500 outline-none">
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</div>
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</div>
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</div>
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</div>
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</div>
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</div>
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<script type="module" src="js/app.js"></script>
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</body>
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</html> |